1. Its all in the details--each supporter of your organization is like a big puzzle and the more details you have, the more you can effectively target your supporters. Having a detailed profile is essential to targeting your supporters.

For example, knowing that "John Doe" is a 20 year old college student in Charlottesville who cares deeply about a number of issues and enjoys your occasional emails, but absolutely won't volunteer or donate to your cause. It's beneficial to him because you won't have to bother him unnecessarily and it's beneficial to your organization because it saves you valuable time and money. So, if I wanted to find supporters like John, I might create a query that looks like this: 

On opposite spectrum, knowing that "Jane Doe", John's mother, is a super volunteer in Charlottesville who specifically cares about saving Charlottesville's endangered albino grasshopper is equally essential--she can not only help set up events in the area (or even host them) and contribute to your cause, but also, you know what's important to her. So, you can explain your organization's mission in the context of what she believes is the most important. In that case, I may like to know that she is super invested in grasshoppers and a frequent event attendee, I might run a query like this to find supporters like Jane.

2. Community based organizing--the much overused phrase, "all politics is local" is overused for a reason. If you are an environmental organization, your supporters in Grundy County, Tennessee may care about the same national issues that your organization focuses on--but they also care about major local environmental issues like runoff into the local reservoir. This isn't to say that you need to diversify the focus of your larger message--but its important to be aware of the motivation and interests of your supporters. In Salsa, you can use the "notes" field or

a BLOB field to store this kind of information. 

3. Assuming makes an erm...jerk of you and me--don't assume that everyone who is a supporter of your organization as a whole whole-heartedly supports everything your organization is going to do. By using 1 and 2 (listed above), you can target your supporters based on their geography and interests to make sure that your organization is simultaneously meeting your needs and meeting the needs of your supporters. For example, if you have a local DC issue--you can run a query  this to find every relevant support in the immediate DC area.